The significance of drug-induced spectral changes in liver microsomal fraction
نویسندگان
چکیده
منابع مشابه
TCDD-induced changes in rat liver microsomal enzymes.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a contaminant of the herbicide 2,4,5trichlorophenoxyacetic acid (2,4,5-T), is extremely toxic (1), although the mechanism of toxicity is not known. Other papers presented at this conference cover the spectrum of environmental and health hazards of chlorinated dibenzodioxins and dibenzofurans. It should suffice to say here that these compounds are tera...
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15 صفحه اولBinding of inositol trisphosphate by a liver microsomal fraction.
Accumulating evidence suggests that the increase in cytosolic Ca2+ induced by receptor agonists is mediated by inositol 1,4,5-trisphosphate, a product of phospholipase C-mediated breakdown of phosphatidylinositol 4,5-bisphosphate. The present study employs inositol tris[32P]phosphate to demonstrate a specific receptor binding site in a microsomal fraction of rat liver.
متن کاملDrug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations.
Two predictive tools have been proposed by Austin et al. (Drug Metab Dispos 30:1497-1503, 2002) and Hallifax and Houston (Drug Metab Dispos 34:724-726, 2006) to estimate the fraction unbound in the incubation (fu(inc)). The current study was undertaken to elucidate the relative utility of these prediction tools over a range of drug lipophilicity and microsomal protein concentration. The fu(inc)...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1971
ISSN: 0306-3283
DOI: 10.1042/bj1250008p